England were dismissed for 204 thanks to West Indies' captain Jason Holder's superb 6-42 on day two of the first Test at an empty Southampton.
Holder, who at one stage took 3-1 in 14 deliveries, was backed up by 4-62 from the pacy Shannon Gabriel.
On a pitch offering plenty for the bowlers, England's batsmen showed obvious signs of rustiness in their first Test since the coronavirus lockdown.
Captain Ben Stokes was dropped twice in his 43, wicketkeeper Jos Buttler briefly impressed for 35, and it needed a last-wicket stand of 30 between Dom Bess, who made 31 not out, and James Anderson to carry England past 200.
England were then not at their best with the ball, with West Indies moving to 57-1, 147 behind.